FreshBodyLab is reader-supported. As an Amazon Associate I earn from qualifying purchases β at no extra cost to you.
SkinMedica TNS Advanced+ Serum is one of the most premium serums on Amazon β and one of the most respected in professional skincare. When a product costs this much, you want to use it perfectly. The good news: it’s simple once you understand the two-chamber design.
This guide explains what’s in the bottle, how to dispense and apply it, where it fits in your morning and evening routines, what to pair it with and how to make each bottle last.
Quick guide summary
SkinMedica TNS Advanced+ Serum
Prices and availability are shown on Amazon and may change.
π In this guide
What’s in the Bottle?
TNS Advanced+ keeps two formulas apart until you pump, so each stays stable and effective:
| Chamber | What’s inside | Job |
|---|---|---|
| Chamber 1 | Next-generation growth factor blend + peptide complex | Supports healthy skin function and nourishes skin |
| Chamber 2 | Renessensce (RSC) Advanced: marine extract + green microalgae | Supports the growth factor blend |
The goal: smoother-looking fine lines and coarse wrinkles, and help with the look of sagging skin. SkinMedica reports visible results in as little as two weeks, and it’s suitable for all skin types.
| Use it | Once or twice a day (AM and/or PM) |
|---|---|
| Amount | One full pump for face and neck |
| Apply to | Clean, dry skin β before moisturizer and SPF |
| Avoid | The eye area |
| Size | 1 fl oz |
| Store | Cool, dry place away from sunlight |
Step-by-Step: How to Apply
- CleanseUse a gentle cleanser and pat dry.
- Prime the pump (first use only)Pump a few times until both formulas come out evenly.
- Dispense one full pumpOne pump releases both formulas. Mix them together in your palm or on your fingertips.
- Apply to face and neckSmooth over face and neck, avoiding the eye area. Press gently until absorbed.
- Continue your routineAdd eye cream, moisturizer and β in the morning β sunscreen.
Pro tip: Use TNS Advanced+ morning and evening for maximum results, or once a day if you want the bottle to last longer. Consistency matters more than quantity.
Ready to upgrade your serum step?Check the latest price, deals & reviews on Amazon.
Check Price on Amazon βWhere It Fits in Your Routine
The rule of thumb: thinnest to thickest, with treatment serums like TNS right after cleansing.
| Step | Morning | Evening |
|---|---|---|
| 1 | Gentle cleanser | Double cleanse |
| 2 | TNS Advanced+ | TNS Advanced+ |
| 3 | Vitamin C (optional) | Retinol on retinol nights (after TNS absorbs) |
| 4 | Moisturizer | Moisturizer |
| 5 | Sunscreen SPF 30+ | β |
Smart Pairings
- At night: SkinMedica Retinol Serum 1.0 for cell renewal β a classic professional anti-aging duo.
- For hydration: PCA SKIN Hyaluronic Acid Boosting Serum after TNS on dry days.
- In the morning: protect your investment with SPF like EltaMD UV Clear or Revision Intellishade SPF 45.
Tips to Protect Your Investment
- Store it cool and away from sunlight β a sunny bathroom windowsill is the worst spot.
- Don’t over-pump. One pump is designed to cover face and neck.
- Close it properly after each use.
- Avoid harsh scrubs on the same day to keep skin calm.
- Use it on the neck too β it’s an area that shows sagging early.
Good to know: Some people notice a distinctive, slightly earthy scent from the growth factors. It fades quickly once absorbed.
Results Timeline
Do’s and Don’ts
β Do this
- Use one pump, mixed, on clean skin
- Apply before moisturizer and SPF
- Store away from heat and sunlight
- Wear sunscreen every morning
β Avoid this
- Pumping 2β3 times “for extra results”
- Applying around the eyes
- Skipping SPF (sun damage undoes the work)
- Giving up before 6 weeks
How Long Does a Bottle Last?
- Twice daily: about 1β1.5 months
- Once daily: about 2β3 months
Many people use it once a day to get great results at half the monthly cost.
Frequently Asked Questions
Can I use TNS Advanced+ with retinol?
Can I use it with vitamin C?
Is it suitable for sensitive skin?
Why does it smell a little earthy?
Do I need to use it twice a day?
Can I use it after in-office treatments?
The Bottom Line
One pump, mixed, applied to clean skin once or twice a day β then protect with SPF. That’s how to get your money’s worth from TNS Advanced+.
Read our TNS Advanced+ review to decide if it’s right for you.
READY TO TRY IT?
SkinMedica TNS Advanced+ Serum
A two-chamber growth factor + peptide serum for the look of lines, wrinkles and sagging.
See Today’s Price on Amazon βPrices and availability change often β Amazon shows the current price at checkout.Keep reading
Get Your Free 7-Day Body Care Reset
Tell us whatβs bothering your skin β dryness, breakouts, dark spots, bumpy armsβ¦ Weβll build a simple day-by-day skin-care plan for your exact concerns and send it to your inbox.
7-Day Meal & Workout Plan
Personalized meals and home or gym workouts, sent to your inbox.
- π₯ Calorie & protein targets
- πͺ Workouts for your level
- π Matched to your diet